A couple of months ago Capture One Pro 11 was published. It now fully supports layers i.e. all available tools like exposure, saturation, high dynamic range, curves, levels, clarity, sharpen etc. etc. can be applied to a max. of 16 layers. Layer masks can now be refined and the opacity of layers can be adjusted. I really appreciate these additional options and have started to re-visit a lot of my RAW files. For the attached image I added 3 layers: one for the sky, one for the city and one for the buildings in the foreground (here I used some burning to make them less visible). I still call this 'keeping it natural' because this is how I remember the view at the time I was there.
Of course I still love my Topaz products and will use them frequently. Still CO is going from a RAW converter/asset management software towards a full image editor which I very much like. BTW I can 'call' Topaz Studio right from CO which works nicely.