Please Note: things are not different with 0.8.2. If another plug-in has been used and then I try to also use Simplify, it crashes. If I use Simplify without first applying one or more other plug-ins, it works fine. Thus far, this has only been a problem with Simplify. On the same dng file, I applied Basic Corrections, then Clarity, then Detail and finally Adjust, and I had no problems. One further thing to note: if I work inside of Studio 0.8.2 and apply multiple presets and plug-ins, followed by saving all of that to a Layer in PSCC, and then take that Layer back into Studio and apply Simplify, that also works fine.
On a separate issue, if inside of Studio, I open Impression2, it takes forever for the preset thumbnails to render.