II believe the Microsoft Surface Book and recently announced Surface Book 2, both of which may be configured with nVidia discrete graphics, should be capable of running Topaz Studio and other GPU-intensive products. The Microsoft Studio and recently announced Studio 2 may also be configured with a discrete graphics card, but that option is not available for the recently announced Surface Pro 6.
You will probably spend somewhere between $2,500 and $5,000 (USD) to get a Microsoft Surface product with discrete graphics. This is why I decided to go with a Surface Pro 4, which was purchased to replace a more-than-ten-year-old laptop. The Surface Pro 4 more than adequately runs the newest versions of the Adobe Photographic suite of products, Serif Software's Affinity products (Photo, Designer, and Publisher, which is now in public beta), the Topaz Labs plugins (with the exception of ReMask 5), all my current DxO products, and all my other image processing products including any add-ons and plugins for these products (with exception of Topaz Studio).